Valium

Pharmacological action:

Anksiolitichesky agent (tranquilizer) of a benzodiazepine number. Renders sedatively-soporific, anticonvulsant and central миорелаксирующее action. The mechanism of action of Diazepamum is caused by stimulation of benzodiazepine receptors супрамолекулярного GAMK-BENZODIAZEPINE-HLORIONOFOR of the receptor complex, leading to intensifying of inhibiting action ГАМК (a mediator pre - and постсинаптического inhibitions in all departments TSNS) on transfer of nervous impulses. Stimulates the benzodiazepine receptors located in the allosteric centre постсинаптических of GAMK-RECEPTORS of the ascending activating reticular formation of a brainstem and intercalary neurones of lateral horns of a spinal cord; reduces excitability of subcortical structures of a brain (the limbic system, a thalamus, a hypothalamus), brakes полисинаптические spinal reflexes

Application:

Disturbing disorders. A dysphoria (as a part of the combined therapy as additional ЛС). A sleeplessness (difficulty of a backfilling). A spastic stricture of sceletal muscles at a local trauma; the spastic conditions bound to a lesion head or a spinal cord (a cerebral paralysis, an athetosis, a tetanus); a myositis, a bursitis, an arthritis, rheumatic пельвиспондилоартрит, a progressing chronic polyarthritis; an arthrosis accompanied by a strain of sceletal muscles; вертебральный a syndrome, a stenocardia, a strain headache. An abstinent alcoholic syndrome: uneasiness, intensity, agitation, a tremor, transitional reactive conditions. As a part of complex therapy: an arterial hypertensia, a peptic ulcer of a stomach and 12-perstnoj intestines; psychosomatic disorders in obstetrics and gynecology: climacteric and menstrual disorders, гестоз; the epileptic status; an eczema, etc. the diseases accompanied by an itch, irritability. Illness Меньера. Poisonings ЛС. A premedication before operative measures and endoscopic manipulations, the general anaesthesia. For parenteral introduction: a premedication before the general anaesthesia; as a component of the combined general anaesthesia; a myocardial infarction (as a part of complex therapy); impellent excitation of a various aetiology in neurology and psychiatry; paranoidly-galljutsinatornye conditions; epileptic attacks (cupping); simplification of patrimonial activity; premature birth (only in the end of III trimester of pregnancy); premature отслоение placentas

Contraindications:

Hypersensitivity, a coma, a shock, an acute drunkenness with weakening of the vital functions, the acute intoxications ЛС, having oppressing an effect on ЦНС (including narcotic analgetics and soporific ЛС), a myasthenia, an angle-closure glaucoma (an acute attack or predisposition); serious ХОБЛ (danger of advance of degree of respiratory insufficiency), acute respiratory insufficiency, an absentia epileptica or syndrome Lennoksa-Gasto (at i.v. introduction pregnancy (especially I trimester), the lactemia period, children's age to 6 мес (promotes occurrence of the tonic epileptic status), at intake), till 30 days inclusive (at в/м and i.v. introduction).C care. Epilepsy or epileptic attacks in the anamnesis (the beginning of treatment by Diazepamum or its sharp cancellation development of attacks or the epileptic status), hepatic and-or renal insufficiency, cerebral and spinal атаксии, hyperkinesias, medicinal dependence in the anamnesis can accelerate, predilection to abusing psychoactive ЛС, organic diseases of a brain, a hypoproteinemia, night апноэ (established or assumed), advanced age.

Side effects:

From nervous system: in the treatment beginning (especially at elderly patients) - drowsiness, giddiness, undue fatigability, depression of ability to concentration of attention, атаксия, a disorientation, instability of a gait and bad coordination of movements, slackness, an obtusion of emotions, retardation of mental and impellent reactions, an ecmnesia (develops more often, than at reception of other benzodiazepines); seldom - a headache, euphoria, depression, a tremor, depression of mood, a catalepsy, confusion of consciousness, dystonic extrapyramidal reactions (uncontrollable movements of a body, including eyes), delicacy, a myasthenia within day, a hyporeflexia, a dysarthtia; extremely seldom - paradoxical reactions (aggressive flashes, psychomotor excitation, pavor, suicidal bent, a muscular spastic stricture, confusion of consciousness, hallucination, acute excitation, irritability, uneasiness, a sleeplessness). From hemopoiesis organs: Leukopenia, neutropenia, agranulocytosis (a fever, a hyperthermia, a pharyngalgia, excessive fatigability or delicacy), an anaemia, a thrombocytopenia. From the alimentary system: dryness in a mouth or a hypersalivation, a heartburn, a hiccup, a gastralgia, a nausea, vomiting, appetite depression <http://click01.begun.ru/click.jsp? zLh-dTBJm*F1IjiQ>, constipations; disturbances of function of a liver, rising of activity of "hepatic" transaminases and ??, an icterus. From party SSS: palpitation, a tachycardia, BP depression (at parenteral introduction). From genitourinary system: Urine incontience, ischuria, disturbance of function of kidneys, rising or depression либидо, a dysmenorrhea. Allergic reactions: a dermal eruption, an itch. Influence on a foetus: тератогенность (especially I trimester), oppression ЦНС, disturbance of breath and suppression of a sucking reflex at the newborns which mothers applied a preparation. Local reactions: in an introduction place - a phlebitis or a venous clottage (a redness, a tumescence or a pain in an introduction place). Other: accustoming, medicinal dependence; seldom - oppression of the respiratory centre, disturbance of function of external breath, disturbance of sight (diplopia), a bulimia, depression of mass of a body. At a sharp dose decline or the reception termination - a "cancellation" syndrome (irritability, a headache, uneasiness, excitement, excitation, feeling of pavor, nervousness, dream disturbances, a dysphoria, a spastic stricture of unstriated muscles of internal organs and a sceletal musculation, a depersonalisation, diaphoresis intensifying, depression, a nausea, vomiting, a tremor, perception disorders, including a hyperacusia, paresthesias, a photophobia, a tachycardia, cramps, hallucinations, it is rare - an acute psychosis).